8ml sachets are packed in boxes of 500 sachets. Why Paraben Free - Paraben - Oestrogen Connection Suspicions concerning Parabens and cancer first appeared back in 1998. At that time, studies began to expose the oestrogen-like property of Parabens. Twelve studies have confirmed oestrogen-like activity in laboratory rats injected with Parabens. The results indicate a weak form of estrogen, but it's there. On a positive note, the researchers found that Parabens ingested orally show no Oestrogen activity. It appears that Parabens in food and medications are insignificant. (Well that's good news!)